Don MacLeod, Debra Macleod's 50 Ways to Play: BDSM for Nice People PDF

By Don MacLeod, Debra Macleod

ISBN-10: 0399163468

ISBN-13: 9780399163463

This uncomplicated and highly obtainable non-fiction consultant to BDSM (Bondage, Dominance, Sadism, and Masochism) positive aspects 50 edgy and erotic adventures to pattern and is the perefct spouse for the thousands of fanatics of the Fifty colors trilogy (Fifty colours of gray, Fifty colors Darker and Fifty colors Freed), the Anne Rice/A.N. Roquelaure Sleeping Beauty trilogy (The Claiming of Sleeping Beauty, Beauty's Punishment, Beauty's Release) and Sylvia Day's Crossfire novels (Bared to You and Reflected in You). This guide booklet for includes one caution: you should do that at home!

From turning your ho hum bed room right into a “Red Room of Desire,” to exploring the high-quality artwork of jap rope bondage—and a number of different principles possibly larger no longer pointed out in well mannered company—50 how you can Play invitations who may perhaps another way examine themselves as “average” or “nice” to stroll at the wild part. based on husband-and-wife writers Debra and Don Macleod, intercourse may still pack a punch—it’s intended to trap you off defend. The fifty horny and fantastic “ways to play” provided up during this publication are sure to ensue the warmth on your intercourse life.

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1981; PUnnonen et al. 1983). 34 Leonard Share and Joan T. 01 (I YS gonadectomized. 01 (Male I +V +T YS Female) +E +P +EP Fig. 2. The plasma vasopressin concentration (PADH) in intact (I) male and female rats and in gonadectomized male and female rats treated with vehicle (+V), testosterone (+7), 17~-estradiol (+E), progesterone (+P), and progesterone plus estradiol (+EP). (From Crofton et aI. v. at graded doses, we found that the pressor response to this honnone was greater in male rats than in randomly cycling females (Crofton et al.

1979), and ventricular myosin isoenzyme pattern has therefore been proposed. The results of the study of Lengsfeld et al. (1988), however, suggest that androgens dissociate the ventricular myosin isoenzyme pattern from both cardiac hypertrophy and blood pressure. It has been shown (Hoh et al. 1978) that both types of myosin isoforms may respond differently to elevated levels of cyclic AMP caused by ~-adrenergic stimulation: cyclic AMP increases VIA TPase activity and reduces V3 ATPase activity.

The treated animals showed an accelerated development of hypertension, and their blood pressure reached the level of male TGR(mREN2)27. In contrast, dihydrotestosterone did not significantly change blood pressure of normotensive Sprague-Dawley rats (Fig. 3b). In adult female TGR(mREN2)27, however, dihydrotestosterone treatment did not modify blood pressure. Castration of 4-week-old male TGR(mREN2)27 significantly attenuated and reduced the development of hypertension. The experiments perfonned in TGR(mREN2)27 thus show that these transgenic rats provide a useful model system to investigate the role of local tissue RAS in the pathophysiology leading to the sexual dimorphism concerning blood pressure and hypertension.

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50 Ways to Play: BDSM for Nice People by Don MacLeod, Debra Macleod


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